Exemestane encapsulated vitamin E-TPGS–polymeric nanoparticles: preparation, optimization, characterization, and in vitro cytotoxicity assessment

Preparation, characterization and in vitro cytotoxicity evaluation of docetaxel nanoparticles against A549 cell line

Introduction: Docetaxel (DTX) is one of the most potent anticancer drugs in the taxane family. The commercial formulation of DTX for clinical use consists of high concentrations of tween80, which has been caused serious patient`s difficulties. Therefore, preparation of novel drug delivery system with ability of removing tween 80 and targeting on cancer tissue can lead more effective and also de...

preparation, statistical optimization, and in vitro characterization of insulin nanoparticles

Simultaneous loading of 5-florouracil and SPIONs in HSA nanoparticles: Optimization of preparation, characterization and in vitro drug release study

Objective(s): Over the past two decades, considerable interest has been focused on utilizing biocompatible magnetic nanoparticles (MNPs) for biomedical applications. In this study, production of human serum albumin (HSA) nanoparticles using desolvation technique that were simultaneous loaded with high amounts of superparamagnetic iron oxide nanoparticles (SPIONs) and 5-flourouracil (5-FU) was i...

preparation, physicochemical characterization and in vitro cytotoxicity effect of folate targeted nanoparticles

active targeted nanoparticles: preparation, physicochemical characterization and in vitro cytotoxicity effect

in this study, the folate decorated biodegradable poly (lactide-co-glycolide) (plga) nanoparticles were developed for tumor targeting of anticancer agents. due to the overexpression of the folate receptor on tumor surface, the folate has been efficiently employed as a targeting moiety for various anticancer agents to avoid their non-specific attacks on normal tissues and also to increase their ...